Aras Mattis was born in Los Angeles and grew up with among the Lithuanian-American community in California. He completed his undergraduate studies at the University of California, Berkeley and his Medical and PhD degrees at the University of Illinois at Urbana-Champaign with doctoral mentor Richard Gumport. Aras went on to complete residency at the University of California San Francisco (UCSF) as a Pathologist with specialization in liver and gastro-intestinal pathology.
His post-doctoral research involved understanding microRNA regulation of lipid metabolism and the modeling of human liver diseases using induced pluripotent stem cells (iPSCs). Aras recently established his own laboratory at UCSF and uses iPSCs to student human fatty liver disease.
Summary of the Mattis’ Lab:
The Mattis laboratory is focused on understanding human liver metabolism and the molecular mechanisms leading to non-alcoholic fatty liver disease. The goal is to use advanced human cell culture and xenograft human in mouse liver repopulation models to truly understand human metabolism. The larger goal is to use these techniques to develop targeted cures for human fatty liver disease and cancers of the liver. In order to quickly and effectively accomplish their goals, they use iPSC-derived hepatocytes and high content analysis in addition to genetic mouse models. They also have projects looking at Cystic Fibrosis Liver Disease and Deep Sequencing of Cholangiocarcinoma.